microcollections

鏈接：https://microcollections.de/

EMC microcollections成立于1996年7月，由Günther Jung教授、Friedrich Stracke博士和Karl-Heinz Wiesmüller教授共同創(chuàng)建，總部位于德國，是一家專門從事生物活性化合物和化合物庫服務(wù)的公司。他們提供TLR配體、生物活性肽、肽表位、抗微生物肽等各種生物活性化合物、肽和化合物庫，以滿足科研人員和生命科學(xué)領(lǐng)域的需求。公司致力于為客戶提供高質(zhì)量的化合物和專業(yè)的化合物庫服務(wù)，幫助他們在藥物研發(fā)和生命科學(xué)研究方面取得成功。

EMC microcollections提供廣泛的基礎(chǔ)生化試劑工具。

EMC microcollections生化產(chǎn)品目錄包括：

l用于Toll樣受體研究和輔助劑的工具，比如用于TLR1/2研究的脂肽肽（例如Pam3Cys-SKKKK及其類似物），用于TLR2/6研究的脂肽（例如Pam2Cys-SKKKK或FSL-1及其類似物）。

l生物活性肽，淀粉樣?-肽，用于多發(fā)性硬化癥研究的肽，MHC-I和II限制性肽表位，細(xì)胞穿透肽，微生物和抗微生物肽。

EMC microcollections在脂肽和TLR配體領(lǐng)域發(fā)表的部分文獻(xiàn)

1. K. Deres, H.-J. Schild, K.-H. Wiesmüller, G. Jung, and H.-G. Rammensee (1989) In vivo Priming of Virus Specific Cytotoxic T-Lymphocytes with Synthetic Lipopeptide Vaccine. Nature 342, 561-564.

2. K.-H. Wiesmüller, G. Jung, and G. Hess (1989) Novel Low-Molecular-Weight Synthetic Vaccine Against Footand-Mouth Disease Containing a Potent B-Cell and Macrophage Activator. Vaccine 7, 29-33.

3. F. Wiedemann, R. Link, K. Pumpe, U. Jakobshagen, H. E. Sch?fer, K.-H. Wiesmüller, R.-P. Hummel, G. Jung, W. G. Bessler, and T. B?ltz (1990) Histopathological Studies on the Local Reactions Induced by Complete Freund's Adjuvant (FCA), Bacterial Lipopolysaccharide (LPS) and Synthetic Lipopeptide (P3C) Conjugates.J. Pathology 164, 1-7.

4. K.-H. Wiesmüller, W. G. Bessler, and G. Jung (1992) Solid Phase Peptide Synthesis of Lipopeptide Vaccines Eliciting Epitope-Specific B-, T-Helper and T-Killer Cell Response. Int. J. Pept. Prot. Res. 40, 255-260.

5. R. Spohn, U. Buwitt-Beckmann, R. Brock, G. Jung, A. J. Ulmer, and K.-H. Wiesmüller (2004) Synthetic Lipopeptide Adjuvants and Toll-like Receptor 2 – Structure-Activity Relationships. Vaccine 23, 2494-2499.

6. U. Buwitt-Beckmann, H. Heine, K.-H. Wiesmüller, G. Jung, R. Brock, S. Akira, and A. J. Ulmer (2005) Toll-Like Receptor 6-Independent Signaling by Diacylated Lipopeptides. Eur J Immunol. 35, 282-289.

7. F. Reutter, G. Jung, W. Baier, B. Treyer, W.G. Bessler, K.-H. Wiesmüller (2005) Immunostimulants and Tolllike receptor ligands obtained by screening combinatorial lipopeptide collections. J. Pept. Res. 65, 375-383.

8. U. Buwitt-Beckmann, H. Heine, K.-H. Wiesmüller, G. Jung, R. Brock, S. Akira, and A. Ulmer (2006) TLR1- and TLR6-Independent Recognition of Bacterial Lipopeptides. J. Biol. Chem. 281, 9049-9057.

9. A. B. Schromm, J. Howe, A. J. Ulmer, K.-H. Wiesmüller, T. Seyberth, G. Jung, M. Rossle, M. H. J. Koch, T. Gutsmann, and K. Brandenburg (2007) Physicochemical and Biological Analysis of Synthetic Bacterial Lipopeptides: Validity of the Concept of 'Endotoxic Conformation. J. Biol Chem. 282, 11030-11037.

10. S. Voss, A. J. Ulmer, G Jung, K.-H. Wiesmüller, and R. Brock (2007) The Activity of Lipopeptide TLR2 Agonists Critically Depends on the Presence of Solubilizers. Eur. J. Immunol., 37, 3489-3498.

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